Preheat the oven to 300°F (149°C).
In a mixing bowl, combine the crushed garlic, smoked paprika, mustard seeds (or whole grain mustard), neutral oil, honey, salt, and black pepper. Mix until well combined.
Place the chuck roast in an oven-safe roasting pan.
Pour the marinade over the chuck roast, and spread it evenly over the entire surface of the meat.
Cover the roasting pan with a lid or foil.
Bake the chuck roast in the oven for 3 1/3 to 4 hours, until the meat is tender and falls apart easily with a fork.
Alternatively, you can cook the chuck roast in an Instant Pot. Place the meat in the pot and add 3/4 cup of chicken soup or water. Cook on high pressure for 1 hour.
Once the chuck roast is cooked, remove it from the oven or Instant Pot and let it rest for a few minutes before serving.
Slice the meat and serve it with your favorite side dishes. I like to serve it with roasted vegetables, but it also goes well with mashed potatoes or a side salad.